What you do for a living Essay Example for Free

What you do for a living Essay Ever wonder why it is that you do what you do for a living? Or why you ever chose to go into the career of dental hygiene in the first place. We’ll I got my answer just the other day as I was practicing my clinical hygiene skills. When I heard that I was having a patient come in that was physically and mentally challenged, I had no idea what was going to be presented to me as a clinician. John Doe showed up and when I went out to get him he had a care taker with him. He had to be lead and helped to my chair for observation. Not knowing his medical history I really had no idea of what kind of special needs patient he was going to be. At first when I asked him to take a seat at my chair he just stood there and did not even say a word. I was nervous not knowing if I was handling the situation well enough. His care taker finally said in a forceful voice, â€Å"John sit down!† I was trying to communicate with him in a friendly way, and I could tell that he was really nervous about the appointment. As I went through his medical history with his care giver, I found it very frustrating that she did not know why he was taking any of these medications. However, there was a list of his conditions, so I had to use my best judgment. Also the company had no information on his dental history. I personally don’t think he ever had a dental history, which really bothered me to know that he wasn’t getting his teeth taken care of. John has Down syndrome, with severe mental retardation, along with many other conditions, most of which I found to be linked to each other. As we started leaning him back in the chair I could tell that he was unsure if he liked what was going on. I found that I had to adjust my level to almost a kid style of learning, showing everything I did before I proceeded onto the next step. I continued talking to him about each step. When I asked him, â€Å"John do you brush your teeth?† He replied the only way he could, with a sign, his caregiver then told me he was saying yes. This was great news; I got some communication out of him, which meant that he was feeling a little more comfortable? As I did the periodontal assessment I was amazed at how much biofilm was on his teeth. Every tooth was completely covered with biofilm and it was even colored it had been there so long. Also he had some mobility on a few teeth. I asked  his caregiver if she was able to brush their patient’s teeth, and she mentioned that they have to have a certain approval to do so. I mentioned that it would be beneficial for John’s health, for her to get approved, due to his limited dexterity to properly take care of his own oral hygiene. John ended up being rated a 4/3.5 deposit evaluation. After John left the clinic I thought to myself AHA, this is why I got into dental hygiene, is to help people in need. This new knowledge will affect patient care in the future as a student. I will not be so quickly to judge whether or not a physically and mentally challenged person will be easy to treat. Seeing this patient made me realize how difficult it is to be a clinician, and how you have to adjust yourself to each individuals needs. It really does take a lot of extra time to focus on proper oral hygiene care for these special patients. My patient care as a future dental hygienist will be definitely affected. I realize now that there are a lot of people, especially special needs patients that aren’t getting the oral health care they need and deserve. As a future dental hygienist I know that we need to get out into the public and fight for our services to be utilized for patients that are lacking oral health. People like the special needs patients, and people in nursing homes, will be a huge target population for me. I have now seen proof that the systems taking care of these people need to be educated, and shown how to properly utilize oral health and the link to the body as a whole. It would be nice to get some of my own programs going in order to further benefit these patients. Most likely after seeing what I saw with this patient, I will do volunteer work and help the people that have the least likely opportunity to oral health care. After my experience I remember why it is that I am working towards a career in dental hygiene. I will be able to practice my clinician skills and put forth the effort to benefit not only my patients as a student, but when I start practicing in the private dental office. My other focus will be on educating the communities that are underserved. Now, it’s time to get out there and start promoting oral health and overall health and putting my hygiene career to use.

Restrictive health, safety and technical standards Essay Example for Free

Restrictive health, safety and technical standards Essay Technical Standards: Standards and standards-related technical regulations are pervasive features of global commerce, affecting an estimated 80 percent of world commodity trade. These technical specifications make up much of the vocabulary in the exacting language of industry, consumer protection, and government regulation. As such, foreign standards and methods used to assess conformity to standards can either facilitate efficient international trade and its resultant benefits, or they can impede access to export markets. Divergent standards peculiar to a nation or region, redundant testing and compliance procedures, unilateral and non-transparent standard setting exercises, and a confusing thicket of other standards-related problems are now recognized as major impediments to free trade. For example: Vietnams Ministry of Science and Technology publishes a list of imports and exports requiring mandatory quality inspection. Importers and exporters of the products on the list must subject their products to inspection and obtain a permit from the relevant government agencies (such as the Ministry of Public Health, the Ministry of Agriculture and Rural Development, the Ministry of Industry, the Ministry of Fishery, and the Ministry of Science and Technology) at the time they go through customs. In the inspection, some products are subject to national standards, some are subject to regulations of the functional agencies, and some are subject to both. China is very concerned with the transparency of Vietnams mandatory quality inspection system. Language Barrier: Communication is the key to building successful business relationships. However, communication becomes complex when more than one language is involved. Interpreters and translators can play a critical role assisting exporters with the delivery of key information to prospective customers and clients. Interpreters and translators fulfill different roles in different cultures. For example, an interpreter in North America or Europe is expected to relay an unbiased account of the information to the audience. In Japan, however, an interpreter will translate the language and quite likely interpret gestures, context and meanings for those in attendance. Exporters should enlist the services of an experienced, fluent translator or interpreter who is also immersed in the culture of the target market. Working as a team, the exporter and the interpreter can review the text, presentation or other materials together to ensure that there will be no difficulties with background information, technical terms or potentially ambiguous messages. Non-tariff Barriers. Non-tariff barriers (NTBs) refer to the wide range of policy interventions other than border tariffs that affect trade of goods, services, and factors of production. Most taxonomies of NTBs include market-specific trade and domestic policies affecting trade in that market. Extended taxonomies include macro-economic policies affecting trade. NTBs have gained importance as tariff levels have been reduced worldwide. Common measures of NTBs include tariff-equivalents of the NTB policy or policies and count and frequency measures of NTBs. These NTB measures are subsequently used in various trade models, including gravity equations, to assess trade and/or welfare effects of the measured NTBs. Conclusion The world has a long history of international trade. In fact, trading among nations can be traced back to the earliest civilizations. Trading activities are directly related to an improved quality of life for the citizens of nations involved in international trade. It is safe to say that nearly every person on earth has benefited from international trading activities. This may be a good time to reinforce the idea that trade barriers are designed to protect some industries but, in fact they may hurt other industries or even consumers. Economists have found that sanctions dont often reach their political objectives and they come with high costs. A good example is the steel tariff imposed by the Bush administration, on foreign-made steel. President Bush imposed the tariffs, ranging from 8 percent to 30 percent, on some kinds of foreign steel in March 2002, in order to help the U. S. steel industry compete with foreign steel producers. Many U. S. manufacturing companies that use steel, including manufacturers of auto parts and appliances, say that the steel tariffs have raised costs for manufacturers and caused thousands of manufacturing losses. Also, people who buy cars or appliances may have to pay higher prices because of the steel tariffs. The U. S. International Trade Commission recently concluded that the tariffs have caused a $30 million net loss to the U. S. economy. In addition, the European Union is considering retaliatory tariffs against the U.S. TBR (Trade Barrier Regulation) is Europes way of removing obstacles to trade, ensuring that countries abide by the rules of international trade, and providing procedures for resolving international trade disputes. Through the European Commission, its procedures interface directly with WTO dispute resolution procedures, affecting all countries subject to WTO rules and agreements notably the United States and Japan and whose industries have been the subject of recent international decisions. Free trade is usually most strongly supported by the most economically powerful nations in the world, though they often engage in selective protectionism for those industries which are politically important domestically, such as the protective tariffs applied to agriculture and textiles by the United States and Europe. The Netherlands and the United Kingdom were both strong advocates of free trade when they were economically dominant, today the United States, the United Kingdom, Australia and Japan are its greatest proponents. However, many other countries (such as India, China and Russia) are increasingly becoming advocates of free trade as they become more economically powerful themselves. As tariff levels fall there is also an increasing willingness to negotiate non tariff measures, including foreign direct investment, procurement and trade facilitation. The latter looks at the transaction cost associated with meeting trade and customs procedures. Traditionally agricultural interests are usually in favour of free trade while manufacturing sectors often support protectionism. This has changed somewhat in recent years, however. In fact, agricultural lobbies, particularly in the United States, Europe and Japan, are chiefly responsible for particular rules in the major international trade treaties which allow for more protectionist measures in agriculture than for most other goods and services. During recessions there is often strong domestic pressure to increase tariffs to protect domestic industries. This occurred around the world during the Great Depression leading to a collapse in world trade that many believe seriously deepened the depression. The regulation of international trade is done through the World Trade Organization at the global level, and through several other regional arrangements such as MERCOSUR in South America, NAFTA between the United States, Canada and Mexico, and the European Union between 27 independent states. The 2005 Buenos Aires talks on the planned establishment of the FTAA (Free Trade Area of the Americas) failed largely due to opposition from the populations of Latin American nations. Similar agreements such as the MAI (Multilateral Agreement on Investment) have also failed in recent years. Bibliography 1. Barriers to entry: Coping with protectionism. UK Investment. 18 April 2007 http://www. ukinvest. gov. uk/10415/en_GB/0. pdf 2. Boone, L. , and Kurtz, D. Contemporary Marketing. New York: Dryden Press. 2003 3. Brue, S. , and McConnell, C. Economics. New York: McGraw-Hill. 2003 4. Churchill, G. , and Peter, P. Marketing: Creating Value for Customers. Austen Press. 2004 5. Czinkota, M. R. , and Ronkainen, I. A. International Marketing. New York: Dryden Press. 2005 6. Competition and Market Power. Econoclass – Sources for Economics Teachers. 18 April 2007 http://www.econoclass. com/imperfectcompetition. html 7. Deardorff, Alan V. , and Robert M. Stern. Measurement of Nontariff Barriers: Studies in International Economics. 2005 8. Debra Ann Skaradzinski. Testing chaotic dynamics via Lyapunov exponents. Journal of Applied Econometrics 20:7, (2003): 911. 9. Fisher, Ronald, and Pablo Serra. â€Å"Standards and Protection. † Journal of International Economics 52 (2004): 377-400. 10. Farese, L. , Kimbrell, G. , and Woloszyk, C. Marketing Essentials. Mission Hills, CA: Glencoe/McGraw-Hill. 2003 11. Henson, Spencer, and John S. Wilson, eds. The WTO and Technical Barriers toTrade, in the Critical Perspectives on the Global Trading System and the WTO series, Northampton, MA: Edward Elgar Publishing Ltd. 2005 12. Impact of Standards and Technical Regulations on Trade. Press Release from Commerce Ministry (2003). 18 April 2007 http://www. commerce. gov/opa/press/Secretary_Evans/2003_Releases/March/19_Standards. htm 13. Journal of Behavioral Finance, Vol. 4, No. 2, (2003): Pages 65-70 14. Kee, Hiau Looi, Alessandro Nicita, and Marcelo Olarreaga. Estimating Trade Restrictiveness Indices, World Bank Policy Research Working Paper # 3840.2006 15. Kotler, P. , and Armstrong, G. Marketing: An Introduction. Upper Saddle River, NJ: Prentice-Hall. 2004 16. â€Å"Methodologies, Classifications, Quantification and Development Impacts of Non-Tariff Barriers: Note by the UNCTAD Secretariat,† Document TD/B/COM. 1/EM. 27/2. (2004). 18 April 2007 http://www. unctad. org/TEMPLATES/meeting. asp? intItemID=3411lang=1m=10489info=not 17. Non-tariff Barriers Centre for Rural Agricultural Development (2003). 18 April 2007 www. econ. iastate. edu/research/webpapers/paper_12703. pdf 18. RSIE Working Papers. University of Michigan.(2005). 18 April 2007 http://www. fordschool. umich. edu/rsie/workingpapers/wp. html 19. The Impact of Regulations on Agricultural Trade. Working Paper, Centre d’Etudes Prospectives et d’Informations Internationales, Paris. (2003). 18 April 2007 www. econ. iastate. edu/research/webpapers/paper_12703. pdf 20. Trade, Environment and Development. United Nations Conference on Trade and Development (UNCTAD). (2005). 18 April 2007 www. unctad. org/trade_env/ 21. Vousden, Neil. The Economics of Trade Protection. Cambridge, UK: Cambridge University Press. 2005.

Relationship Between Zinc and Heart Disease

Relationship Between Zinc and Heart Disease Otoniel Santiago Shanil Juma, PhD Cardiovascular disease (CVD) is the number one common cause of morbidity and death in all ethnicities. There are many contributing factors associated to this disease, which include: atherosclerosis, type 2 diabetes, high cholesterol, lack of physical activity and obesity1-3. Despite the many studies performed in these areas, nutrition and nutritional status play a major role in the decrease of CVD. One area that has been look at for almost a decade is the relationship of micronutrients in preventing the onset of cardiovascular disease. Although there are still many controversies in the areas of diet and obesity, the role of micronutrients especially zinc, have been closely studied to identify if its levels have any effect in reducing or potentially inducing cardiovascular disease. The purpose of this report will be to briefly discuss how zinc levels may play a role in promoting cardiovascular disease or preventing it. Zinc Functions Zinc is known as one of the essential trace elements vital for maintaining normal physiology and cellular functions in the body.1 It was during the 1960’s that zinc deficiency was discovered after it was found that dwarfism and delayed sexual maturation were related to zinc. This discovery lead to an increase in clinical studies in order to understand the critical role of zinc in human physiological growth and its relation to other conditions such as, dermatitis, impaired taste, and impaired immunity to name a few.1 Nonetheless, the role of zinc is not completely understood. This trace element has only been known for the past 50 years, but it has been clearly documented that it can improve an array of conditions like acute diarrhea in children, the common cold, and reduction of oxidative stress, the making of genetic material and wound healing. In all, zinc plays a major role in protein synthesis, thus, making it one of the most essential micronutrient needed for optimal healt h in the human body. Zinc and Heart Disease Zinc has been known for its many protective capacities and functions. However, low zinc levels have been associated with age, disease and lack of nutritional intake. It has been found that zinc deficiency increases the inflammatory response caused by increased vascular oxidative stress.2 For instance, in patients with type 2 diabetes suffering from cardiovascular disease, it was found that zinc serum levels were low3. Despite the fact that low serum zinc levels were found to be an independent factor for heart disease in patients with type 2 diabetes, non-diabetic patients who suffered from CVD was related to lower consumption of zinc.3 Zinc deficiency can also be associated to malabsorption caused by gastric conditions such as Chron’s disease and celiac sprue, or conditions like diabetes which increase zinc loss due excessive urinary output4. A study conducted by Frustaci et al, looked at selenium and zinc deficiency to identify if cardiac malfunction could occur with individuals who suffer from intestinal malabsorption. The study found that there was a great association of between the deficiency of selenium and zinc and the degeneration of cardiomyocytes5. Although this study looked into two micronutrients, it is important to point out that zinc played a major role in this study. As mentioned previously, zinc is an essential trace element that works in nearly over 300 enzymes exerting catalytic, structural, and regulatory functions4, 5. In addition to these functions, a deficiency of zinc can cause cell apoptosis and necrosis due to its role in growth and development. On the other hand, selenium has been associated with the Keshan disease that causes progressive dilated cardiomyopathy5. Both elements serve as antioxidants detoxifying cardiomyocytes from free radicals and a deficiency of any of these two elements can cause a decline a cardiac function5. Patients in this study were treated with a selenium/zinc infusion of 13.6 mg/d/wk for about six months. The group was divided into two groups consisting of one group of (A2, n=8) and another (A1, n= 10).5 All patients in group A1 received cardiac catherization, and an endomyocardial biopsy, while the A2 group were only treated with anti-heart failure therapy. Nonetheless, after the six months was completed group A1 showed an improvement in their left ventricle dimension when compared to the A2 group who only received supportive therapy5. The study determined that a selenium and zinc cardiomyopathy can occur in patients with intestinal malabsorption and that an infusion of both elements can improve a nd possibly prevent the malabsorption associated cardiomyopathy5. In another study conducted by Soinio et al, after a seven year period follow up on both non-diabetic patients and type 2 diabetic patients, it was found that there was an increase in mortality from CVD in patients with lower serum levels of zinc (≠¤14.1 µmol/l) then those who did not (14.1>  µmol/l)3. Most patients on this study were between the ages of 45-64 and the population consisted of 1,050 patients from West and East Finland where 526 were men and 470 were women. Each participant was examined for zinc serum levels after a 12hr fast. Zinc serum levels were determined through atomic absorption spectrotometry after 10 years from stored samples. Out of the 1,050 participants 156 died of coronary heart disease and 254 patients suffered a myocardial infarction. The rest of the surviving participants were divided in groups of non-insulin treated and insulin treated subjects. Those with insulin treatment had a 15.3  µmol/l of fasting serum zinc levels when compared to the non-insulin treatment that had 15.8  µmol/l fasting serum zinc levels. However, after breaking the result into quartiles the results were that low serum levels were an independent risk factor for coronary heart disease for coronary heart disease and fatal/non-fatal myocardial infarctions in patients with type 2 diabetes3. Nonetheless, most of the lower serum zinc levels found in diabetics was related to urinary zinc excretion when compared to non-diabetics. It is important to point out that zinc play critical role in the synthesis and function of insulin and the inhibition of pathways that can lead to apoptosis and possibly the upregulation caspase genes3. In this study zinc was added to in vitro insulin preparations to extend the time of insulin action. Despite insulin being added to the treatment of 149 of the participants with type 2 diabetes, serum zinc levels had no considerable changes between the two groups. Thus, there is a possibility that zinc supplementation may be useful to prevent atherosclerotic complications in type 2 diabetes individuals3. Another study showed that coronary artery disease was more prevalent among individuals with diabetes4. In the same study patients with coronary artery disease had higher urinary excretion of zinc when compared to those without coronary artery disease. In addition there was no association with the zinc levels and diseased arteries, but there was an increase in urinary zinc loss and the number of diseases arteries4. In relation to diabetes mellitus similar to the study performed by Soinio et al, patients with diabetes excreted greater amounts of zinc when compared to normoglycemic individuals4. Regardless of the zinc loss linked to diabetes mellitus and polyuria, zinc concentration was not associated with the onset of coronary arterial disease. The loss of zinc, on the other hand, correlated to the severity of the coronary artery disease. Consequently, the loss of zinc causes a shift of zinc from the intracellular fluid to the extracellular fluid to maintain homeostasis. Thus, affectin g zinc dependent enzymes such as the activating nuclear factor Ä ¸B and the reduction of nitric oxide bioavailability and the macrophage-mediated oxidative modification of LDL cholesterol along with the inflammatory cascades associated with it that ultimately promote atherogenesis4. On the other hand, zinc only accounts for about 0.1% of total body pool and zinc plasma concentrations are an insensitive marker for whole body reserves. Thus, the use of the urine zinc/24hour ratio is a better marker to reflect the risk of coronary artery disease. This was compared to other studies that identified that children from parents with coronary artery disease had higher zinc urinary levels. Suggesting that genetically predisposed children with coronary artery disease have in a long term, ongoing zinc losses taking place before the manifestations of clinical symptoms4. Yet, the question still remains whether supplementation of zinc in individuals with low zinc serum levels could prove to be beneficial to prevent or eliminate cardio arterial disease. In relation to children Sadoh looked if there was any relationship in loss of serum zinc levels with congenital heart diseases and pneumonia. Sadoh looked at 41 Nigerian children with confirmed congenital heart disease and 41 without congenital heart disease. Because congenital heart diseases with left or right shunt are associated with pulmonary over-circulation, which leads to congestive heart failure, the loss of serum zinc levels seem to be increased with pneumonia6. In addition, it has been shown that patients with heart failure who are also receiving diuretic therapy are prone to develop zincuria. The medications associated with zincuria are thiadize and angiostenin converting enzyme inhibitors. In poor countries like Nigeria, children are forced to live with chronic heart failure and the bronchopneumonia, which as mentioned previously can cause low zinc levels. Another possibility for these children to have low zinc serum levels can be related to poor food intake and absorption that arises from the malnutrition they are exposed to6. All participants were evaluated for congenital heart disease and any febrile conditions that would had altered results. In any case, patients would have had to resolve the febrile condition prior to the commencement of the study. Patients were seen every month for seven months were 3 ml of blood was collected from each person. Serum zinc levels were evaluated using the Dogan et al method and atomic absorption spectrophotometer6. The results showed that the mean zinc levels in children congenital heart disease was 101.3 ± 21.6  µg/dl when compared to the controlled who had 106.5  ± 18.3  µg/dl. In children less than one years of age, the mean serum zinc was the highest at 102.6  ± 30.7  µg/dl when compared to children ten years and older at the lowest levels 94.8  ± 12.4  µg/dl. Sadoh also compared children with bronchopneumonia whose zinc levels were lower 89.5  ± 15.0  µg/dl indicating an increase loss of zinc due to the disease. When compared to children without bronchopneumonia, the zinc levels were at 103.9  ± 22.2  µg/dl6. This study showed that congenital heart failure along with complications such as bronchopneumonia increases the chances of low zinc serum levels. Zinc plays a major role as an acute phase reactant in bronchopneumonia thus, causing its depletion in children with both of these conditions. Whether the patients with severe pneumonia usually have low zinc serum levels, the combination of both pneumonia and congenital heart disease make patients more susceptible to low zinc levels. The same is applied to patients with chronic congenital heart disease, although their levels seem to be lower due to the use of diuretics as a treatment. In all cyanotic congenital heart disease patients had higher levels of zinc when compared to those with acyanotic congenital heart disease6. In this study no zinc supplementation was used, but it can be safe to say that a supplementation could have resulted in improvement of both conditions as seen in the previous studies. Conclusion Zinc appears to have protective effects in coronary artery disease and cardiomyopathy in individuals suffering from type 2 diabetes and children with congenital hearts diseases. Intracellular zinc plays a critical role in the oxidative stress reduction protecting from the inflammatory response caused atherosclerosis, type 2 diabetes, and other diseases. Zinc supplementation has been shown to improve cardiac function and prevent further damage. Thus, its investigation, although emerging in the cardiovascular disease research, its mechanism needs to be better understood in order for it to be used as a preventative and treatment of cardiovascular disease. References Little PJ, Bhattacharya R, Moreyra AE, Korichneva IL. Zinc and Cardiovascular Disease.Nutrition26.11/12 (2010): 1050-057. Abdel-Khalek Abdel-Salam N, Wessam Aly W, Ahmed Hamza S, Mosfata Fahmy H, Kamel Mortagy A. Relation between zinc level and one year mortality among elderly patients with heart failure.Egyptian J H Med. 2014;54:11-14. Soinio M, Marniemi J, Laakso M, Pyà ¶rà ¤là ¤ M, Lehto S, Rà ¶nnemaa T. Serum zinc level and coronary heart disease events in patients with type 2 diabetes. Diabetes Care. 30:523-528, 2007. Giannoglou G, Konstantinou D, Kovatsi L, Chatzizisis Y, Mikhailidis D. Association of Reduced Zinc Status With Angiographically Severe Coronary Atherosclerosis: A Pilot Study.Angiology. July 2010;61(5):449-455. Frustaci A, Sabbioni E, Fortaner S, Farina S, del Torchio R, Tafani M, Morgante E, Ciriolo MR, Russo MA, Chimenti C. Selenium- and zinc-deficient cardiomyopathy in human intestinal malabsorption: preliminary results of selenium/zinc infusion. European Journal Of Heart Failure. February 2012; 14(2):202-210. Sadoh WE, Sadoh AE. Serum zinc values in children with congenital heart disease. African Health Sciences. September 2013; 13(3):601-606.

To Kill A Mockingbird: Great Quotes By The Characters :: essays research papers

To Kill A Mockingbird: Great Quotes by the Characters Atticus Respectful of other people Talking about Bob Ewell spitting in his face): "I wish Bob Ewell wouldn't chew tobacco." Page 220 Chapter 23 Responding to Jem talking about Mrs. Dubose not being a lady: "She was. She had her own views about things, a lot different from mine, maybe...son, I told you that if you hadn't lost your head I'd have made you go and read to her. I wanted you to see something about her-I wanted you to see what real courage is, instead of seeing courage is a man with a gun in his hand. It's when you know you're licked before you begin but you begin anyway and see through it no matter what. You rarely win, but sometimes you do. Mrs. Dubose won, all ninety-eight pounds of her. According to her views, she died beholding to nothing and nobody. She was the bravest person I ever knew." Page 116 Chapter 11 Talking to Scout: Atticus turned his head and pinned me to the wall with his good eye. His voice was deadly: "First, apologize to your aunt." Page 138 Chapter 14 Talking to Jem: "Mr. Cunningham was part of a mob last night, but he is still a man. Every mob in every little Southern town is always made up of people you know- doesn't say much for the, does it?" Page 160 Chapter 16 Determined Talking to Scout: "Scout, simply by the nature of the work, every lawyer gets one case in his lifetime that affects him personally. This one's mine I guess. You might here some ugly talk about it at school, but do one thing for me if you will: you just hold your head high and keep your fists down." Page 80 Chapter 9 Talking to Scout: "Simply because we were licked a hundred years before we started is no reason for us not to try and win." Page 80 Chapter 9 Talking to Calpurnia: Atticus' eyes filled with tears. He did not speak for a moment. "Tell them I'm very grateful," he said. "Tell them- tell them they must never do this again. Times are too hard...." Page 216 Chapter 22 Talking to Calpurnia: Atticus' eyes filled with tears. He did not speak for a moment. "Tell them I'm very grateful," he said. "Tell them- tell them they must never do this again. Times are too hard...." Page 216 Chapter 22 Clever Talking to Mayella Ewell: "You're becoming suddenly clear at this point. A while ago you couldn't remember too well, could you?" Page 189 Chapter 18

verizon center :: essays research papers

Building facilities like the Verizon Wireless arena and other large sporting and special event venues can be costly. The cost of the Verizon Wireless Arena cost roughly $60 million dollars to compose. Many factors go into this finalized $60 million dollar facility, such as the cost per square foot, the cost per A and B space, and operational costs. To figure out how much money goes into the arena, it is important to keep track of how much income is generated and what forms of marketing and fundraising are done to promote and create profit for the facility. The Verizon Wireless arena has 230,000 sq. feet, which makes the cost of the facility, $260.87 per square foot. There is a vast amount of costs associated with the operation of the arena, for example: The furniture, fixtures, and equipment purchases- everything from the folding chairs, tables, basketball court, hand tools in the shop, office computers, Zambonis and the scoreboard are just some of the items off a list that is seven pages long in very small print. Other overhead costs include water, sewerage, electricity, phone service, internet access, natural gas, cable TV, staff salaries, and benefit packages. In order to upkeep all the equipment and technology the facility has daily operational costs, these include: labor and materials to repair damage, upgrading of current systems, maintain capitol equipment and perform preventative maintenance. In addition, each event within itself has its own related costs such as: labor and material that are requested by the event that are used exclusively for the event, for example: propane gases for pyro special effects, business equipment the show needs that we rent locally (copiers, fax machines, etc.), labor to convert the facility from hockey to concert mode, event housekeeping, event staff (security, ushers, supervisors, ticket takers, etc.). In order to stay in business a facility must make a great amount of income to flourish in its industry. There are many forms of incoming profits from many sectors of the arena. The most important form is Patron generated sales: tickets, premium seat packages these packages are VIP suites, party suites and club seating. Food and Beverage help to keep the customers satisfied while being entertained by events and is a big money maker. Merchandise is sold at each event and the arena even has its own store for Monarch hockey gear and the football arena team the Wolves sell souvenirs as well.

Gene Therapy for Cystic Fibrosis :: Science Diseases Medical Essays

Gene Therapy for Cystic Fibrosis Modern molecular genetics has given hopes and heartaches to thousands of people around the world. These people are looking towards gene therapy for an answer to their questions. To some people such as NIH director Harold Varmus the answer is a better understanding of basic genetic research and to others the answer is a cure, a hope, that their lethal disease will someday be cured. This essay touches on the background of gene therapy for Cystic Fibrosis (CF), current social and ethical issues facing gene therapy for CF, and some thoughts on the importance of this controversial subject. Gene therapy is the application of the technique where the defect-causing "bad" genes are replaced by correct "good" genes. The idea of gene therapy is to treat the disease by correcting the "bad" DNA (Deoxyribonucleic acid) rather than the current me thod of providing drugs, or proteins not produced by the defective gene. Gene therapy addresses the problem first hand by directly working with the genetic information causing the disease. From the book Shaping Genes, Dr. Darryl Macer says "It is like f ixing a hole in the bucket, rather than trying to mop up the leaking water." There are two kinds of gene therapy, somatic cell gene therapy and germline gene therapy. Somatic cell gene therapy is where genes can be put into specific cells and areas of the body which are affected by the disease. All cellular DNA in our body is essentially the same because it was replicated from the same zygote (fertilized egg). Cel ls differentiate into their respective tissues depending upon which part of the total genome is used. Germline gene therapy is where the correct "good" gene is inserted into the germline in place of the defective "bad" gene, and when reproduction occurs the gene will be passed on to the progeny. Inserting the "good" gene into the very early embryo sta ges of development allows for both germline and somatic cells to be corrected. Government has limited the research to only somatic cell gene therapy such as performed in Cystic Fibrosis research. Cystic fibrosis is one of the most common lethal mutations in humans. The autosomal recessive allele is carried by 1/20 Caucasians, 1/400 couples will have children with the disease, and  ¼ children will be afflicted. If untreated, 95% of affected ch ildren will die before age five (Bell, 1996).

The Goal A Process Of Ongoing Improvement Accounting Essay

The mill green goodss machined assemblies furnished to other workss in the UniWare division as constituents of end-items, and besides sold straight as trim parts assemblies to larger end-user clients. The company has a competent and well-trained staff, each of whom is a capable affair expert in their several maps. UniCo is led by extremely experient directors, each of whom has been exposed to progressively broadened duties for different UniCo maps. UniCo ‘s clients want quality merchandises delivered on-time at a sensible monetary value. In order to command monetary values, UniCo ‘s direction has become progressively efficient at cut downing costs in several operational countries. Fiscal public presentation coverage is provided at every degree of production in keen item so that functional cost budgets can be produced and managed with great preciseness. Automation has been introduced at several degrees to increase production efficiencies and have resulted in unprecedented nest eggs in production clip and station production rate. Even with the debut of the robotics, somehow direction has been able to fulfill the rigorous demands of its nonionized work force to accomplish para in its labour dealingss.Problem faced by Alex ‘s divisionAlex ‘s works portions some not-so-complimentary common traits with real-world organisations. He has orders surrounding on two-months behind scheduled bringing day of the month. He has over $ 20 million in unsold finished goods stock list sitting in a local warehouse. The points that can be delivered are being hurried up through the mill with overtime and particular handling involved at every measure. As a consequence of the bringing slippage, gross revenues are decelerating down, stuff costs are skyrocketing, and every efficiency metric is heading downward at an dismaying rate. Furthermore, the division is confronting an increasing hard currency deficit which in bend might take to its inability to pay rewards. The company informs Alex that he has 3 months to turn around the state of affairs else by the terminal of the financial twelvemonth, UniCo would close down this unprofitable operation and sell them off to a highest bidder. Alex ‘s occupation and calling are now on the line as a new proprietor would non desire to maintain an unprofitable or uneffective director around to run the same organisation.Meeting JonahAlex by pure opportunity ran into person who introduces him to another manner of believing about his state of affairs, his old natural philosophy professor Jonah. Alex, describes his house ‘s investing in mechanization and how it has led to increased productiveness. Jonah, in bend, questions Alex about some cardinal identifiers of productiveness such as diminishing stock list, cut downing disbursals, and selling more merchandises. Although Alex could n't affirmatively react to any of them, at that point, he was confident that the issues faced in his works were merely some annoyance jobs, non the death of his full organisation. Jonah takes a minute to uncover the false belief of logic in Alex ‘s concluding – holding accepted many things without oppugning the common sense in their intent and application. Jonah leaves Alex to chew over the construct of productiveness and what it means to a concern.Identifying the GoalProductivity is defined as carry throughing something in footings of ends. In order to place the end, Alex has a thought session with his works accountant Lou, and they both agree that â€Å" The end of any concern is to increase net net income while at the same time increasing return on investing and hard currency flow, or fundamentally to do money † . Though they arrived at a end, neither was cognizant of a scheme to accomplish all 3 at the same clip.Introduction of new constructsWhen Alex discusses this with Jonah, he reveals that operationally, a concern must increase throughput, while at the same time cut downi ng stock list and operational disbursals. Throughput: Rate at which the system generates money through gross revenues. Inventory: It is the money invested in things intended to be sold. Operational disbursals: All the money spent to change over stock list into throughput. When Alex asks how he ‘s supposed to mensurate these elements, he is reminded by Jonah that, â€Å" We are non concerned with local optimums, † mentioning to conventional cost accounting studies. Jonah is a busy single and Alex realizes that Jonah will supply Alex with the concepts for him to divine the replies to the implicit in constructs. Alex must believe through the replies on his ain.Identifying the Core ProblemAlex takes clip to believe about how the three measurings would use to his peculiar state of affairs. He gathers together his focal point group which consists of Lou, the accountant, Bob, the production director, and Stacey, the stock list control director to bind operational solutions together for the full works. Together they reveal that the beginning of the monolithic stock list is the consequence of overrun of unneeded parts being made to unnaturally maintain the efficiency metrics up. Alternatively of bring forthing what is needed for gross revenues, th e works is bring forthing every individual portion every phase can manage. Capacity for bring forthing needed parts is unavailable because it is being tied up bring forthing the extra parts. Jonah reveals that: Money is most of import to direction over efficiency. Cost accounting is the figure one enemy of productiveness. A works in which everyone is working all the clip is inefficient. Jonah points out that the lone manner to make extra stock list is by holding extra work force. By paring extra capacity to cut disbursals, without cut downing stock list and increasing gross revenues you trigger downward throughput and increased stock list. If you attain merely one or two of the three elements of productiveness measuring, you are non working towards your end – to cut down operational disbursal and cut down stock list while at the same time increasing throughput.Dependent events and statistical fluctuationsJonah reveals that when capacity is trimmed to marketing demands, throughput goes down and inventory skyrockets. The transporting costs of stock list, an operational disbursal, besides go up. This addition tends to countervail the nest eggs presented by the original effort to lower operational costs through labour decreases. If capacity is trimmed to run into demand, demand continues to drop, transporting costs go up, and finally you have no more market left for a mountain of stock list. Two specific phenomena are identified which cause this consequence – dependent events and statistical fluctuations. Dependent events are a series of events that must take topographic point prior to another one beginning, or in other words, the subsequent event depends on the 1s prior to it. Statistical fluctuations are the consequence of certain types of prognostic information that can non be determined exactly. These fluctuations influence anticipation of mistake per centums, market demand estimations, and efforts to mensurate productiveness. Alex understands these 2 phenomena when he goes on a hike trip. During the hiking, he notices that the line of tramps exhibits an uneven form of stretching farther and farther apart the longer they hike. He notices that one tramp Herbie appears to be keeping up the staying behind him. Harmonizing to direction scientific discipline, even though these tramps are all at different rates, their mean rate of advancement should be estimable. This mean rate should go the nominal rate of advancement for the full troop. Alternatively the troop is doing concluding advancement, or finishing the hiking, at the rate of its slowest member, Herbie. The hiking is similar to a set of dependent events capable to statistical fluctuations. Over clip, the fluctuations do non average out, but instead accumulate because the influence of dependent events limits the chances for addition fluctuations. The length of the line of tramps becomes comparable to the entire production clip of a procedure. Alex tries an effort at re-balancing the capacity by puting Herbie at the forepart of the line, that manner the production length wo n't be given to stretch out as earlier. It does n't stretch, but it ‘s still traveling every bit slow as Herbie. Herbie must be made faster, or addition throughput capacity, in order for the whole line to derive throughput. Herbie ‘s back pack burden is lightened and distributed among the troop and the full troop doubles its gait as a consequence of the alteration.Identifying ConstrictionsAlex returns to the works merely to hold his observations in the hike trip confirmed by a production capacity trial. Jonah now introduces the concepts of constrictions and non-bottlenecks. A constriction is any resource whose capacity is equal to or less than the demand placed upon it. A non-bottleneck is any resource whose capacity is greater than the demand placed upon it. If bottleneck capacity is kept equal to demand, and demand beads, costs will travel up ensuing in a loss of money. The aim is to keep capacity at somewhat less than demand. Alex now starts to place the works ‘s constrictions. The two obvious constrictions turn out to be the multi-process mechanization machine and a heat-treating furnace. The multi-process mechanization machine NCX-10 can treat an point taking 16 proceedingss and 10 operators in 10 proceedingss and utilizing merely 2. But there is a six month lead clip to develop a NCX-10 operator because of the forte place demands. And trained operators are go forthing the company faster than it can re-train replacings, so the machine is n't running at full capacity which makes it a non fully-utilized constriction. The furnace is being run at partial tonss because of expediting, another non-fully utilised constriction.Optimizing ConstrictionsIn order to extinguish constrictions, Alex invites Jonah for a works circuit during which he notes that the composing of much of the work-in-process waiting at each of the constrictions is really non-saleable parts destined for warehouse storage. This is concealed extra capacity. He asks about alternate methods which could be used in add-on to the present procedures, turn toing the old retired machines as a possible capacity beginning. He asks if every portion really needs to be processed by the constriction and identifies extra concealed capacity. Alex learns to see utilizing alternate procedures or off-load to increase capacity. Quality controls should be placed prior to a constriction to guarantee the constriction will non be treating faulty parts and blowing valuable constriction procedure clip. Rejecting stuffs prior to the constriction so becomes simple bit instead than devouring extra capacity. Procedure controls at a constriction should be designed to guarantee zero defects based processing to minimise re-work and system impact costs. The squad determines that one of the implicit in causes of their present parts pile-up at the constrictions is because the operator can non state the difference between a bottleneck-destined portion and an ordinary 1. The operator, in an effort to maintain busy, processes batch after batch of non-bottleneck parts when what they truly need to make is work on constriction parts. They attempt a solution for this by puting placing tickets on the parts which are destined for a constriction procedure. The bottle cervix capacity is increased by remembering old machines which ensuing in an addition in constriction capacity. The furnaces are non being manned by dedicated forces to maintain them runing and reloaded during the idle times, so extra forces are assigned to them on a full-time footing. Additionally, some of the constriction chiefs come up with methods of streamlining their procedures to increase throughput at their Stationss. And for a clip, things seem to be bettering – stock lists are easy shriveling and more backlog orders are being filled.New jobs come upA new job is revealed with deficits of non-bottleneck parts now happening in add-on to the constriction parts. This could be potentially a new constriction as a consequence of overtaxing the remainder of the system. Triping a resource and using a resource are non-synonymous because non-bottleneck stuff continued to be fed into the system in order to keep the production efficiency quotas, non-bottlenecks began turning out maximal units of non-bottleneck parts choke offing the work-in-process stock lists at constrictions and at non-bottleneck Stationss. Triping a resource is merely turning it on. Using it means doing usage of the resource in a manner that moves the system towards the end. A new stuff release system was developed which triggers release of constriction stuff merely at the rate at which the constrictions need it, instead than being triggered by non-bottleneck idle clip. Jonah shows that they can utilize the same methodological analysis to develop a release system for stuffs throughout the system. By cognizing when the constriction parts will make concluding assembly, the release of the non-bottleneck stuffs can be timed to co-occur along the other paths.Improvement in consequencesAll the stairss to place and extinguish constrictions resulted in better consequences. Peach was impressed, but non sufficiently to name off the division sale. Alex agrees to another 15 per centum betterment in the net net income in order to turn out that the alterations are non fleeting or alone. As it turns out, Jonah indicates that after burden reconciliation is performed to run into market demand without extra production, the following logical measure is to cut down the batch sizes to cut down the entire capital committedness used during production. Decrease in batch sizes besides reduces the entire clip spent in work-in-process. Less clip spent in production increases the velocity of throughput every bit good as a faster turn-around on client orders. Shorter lead times result in better response to the market demands. The four primary clip constituents include: setup clip, procedure clip, queue clip ( associated with constrictions where parts wait for a machine to go free ) , and wait clip ( associated with non-bottlenecks when a portion waits for another portion to go on treating ) . Time saved at a non-bottleneck is fanciful because when non-bottlenecks are being set up, the clip spent is taken off from idle clip, non production clip. Economic batch measures are calculated based upon the whole system and non the constrictions themselves. As a consequence, most batch sizes are non optimized to the Stationss most affected by them — the constrictions. Now that the works has the potency of reacting better to market demands, Alex focuses on the 3rd constituent of productiveness measuring, that of gross revenues throughput, and gets the division gross revenues director, Johnny Jons, to market his works ‘s improved capacity. Together they manage to bind down a major contract utilizing a combination of incremental bringings and low measure pricing. This sets the phase for carry throughing the 15 per centum betterment Alex promised to Peach.Accounting ImpactSmyth, the division productiveness director and viing works director, sets out to place what Alex is making to his works by originating an internal audit. As a consequence of the labour alterations and the non-bottleneck idle times the cost studies show an addition in per unit costs. Smyth calls Alex in to explicate himself in visible radiation of the audit findings. Alex illustrates specific points that are in direct contradiction with conventional fabrication premises: We should equilibrate the flow with demand, non capacity. The degree of activity from which the system is able to gain is non determined by single potency but by some other restraint in the system. Triping a resource and using it are non the same. An hr lost at a constriction is an hr lost by the full system. An hr saved at a non-bottleneck is worthless. Performance of an operation should be evaluated by its bottom line. Smyth presents his findings – that Alex ‘s works has decreased productiveness, increased merchandise cost, and improper attachment to processs throughout the organisation. This was beliing grounds that the works has turned solid net incomes and lowered operating disbursals, increasing hard currency flow. The division accountant pointed out that Alex ‘s works represents the ideal combination of bringing velocity, low cost, and flexibleness that the market truly needs. With this Alex was appointed as the division director. The ground Alex received support of the division accountant was because Lou, the program accountant had been working hard behind the scenes re-crunching the Numberss and placing an extra defect in the conventional cost accounting procedure – rating of stock list costs. Even though utilizing the hard currency method would clearly show the lessening in work in procedure and finished goods stock list, and decreases in purchased stuff costs, the traditional accrual method shows these actions as period losingss since hard currency payment turning away is non recorded until the following accounting period. In re-calculating the fiscal statements, Lou found a jutting 20 per centum bottom line betterment alternatively of the promised 15. But alternatively of giving these cumbrous accounting accounts to Alex to utilize in his defence, Lou took the consequences straight to Frost, the division accountant who understood the branchings of the NumberssDecision5 primary stairss identified to better procedures are: Identify the system restraints Decide how to work the system ‘s restraints Subordinate everything else to the above determination Promote the system ‘s restraints If in the old stairss, a restraint has been broken, return to Step 1, but do non let inactiveness to do a system ‘s restraint Due to the betterments, the works now has twenty percent extra capacity available to carry through demand. It turned out that Europe has many possible clients, but the monetary values they demand are so low below the domestic market, UniCo could n't perchance take them without losing money. Alex pointed out that when production is used from trim capacity, the lone costs are the cost of the stuffs and as such, any monetary value above stuff cost represents net income. Combined with an unbelievably short bringing clip to close out unimproved rivals, the company has pocketed many trades guarantee the future gross revenues of the works.